Vaccination Guide for
Immunosuppressed Patients with IBD

Side Effects

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SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Infusion-related reactions – sometimes can be managed with pre-medications, IV fluids, or lengthening infusion duration.
  • Increased risk of serious infection (sepsis and pneumonia), invasive fungal infections and viral infections; approximately 10% increased risk at wk 54. Reactivation of latent TB.
  • Can worsen pre-existing CHF.
  • Lupus-like reaction (rare).
  • Anti-TNF–induced psoriasis
  • Hepatocellular damage, hepatitis, jaundice, autoimmune hepatitis; reactivation of HBV.
  • Potential increased risk of malignancy (lymphoma, hepatosplenic T-cell lymphoma, melanoma, and NMSC); increased frequency when used in combination with a thiopurine.
  • Numbness and tingling in legs, arms, etc.
  • Change in vision, weakness in leg, dizziness.
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Infusion-related reactions – sometimes can be managed with pre-medications, IV fluids, or lengthening infusion duration.
  • Increased risk of serious infection (sepsis and pneumonia), invasive fungal infections and viral infections; approximately 10% increased risk at wk 54. Reactivation of latent TB.
  • Can worsen pre-existing CHF.
  • Lupus-like reaction (rare).
  • Anti-TNF–induced psoriasis
  • Hepatocellular damage, hepatitis, jaundice, autoimmune hepatitis; reactivation of HBV.
  • Potential increased risk of malignancy (lymphoma, hepatosplenic T-cell lymphoma, melanoma, and NMSC); increased frequency when used in combination with a thiopurine.
  • Numbness and tingling in legs, arms, etc.
  • Change in vision, weakness in leg, dizziness.
           
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SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Injection-site reactions
  • Headaches
  • Diarrhea
  • Skin rash or itching
  • Possible infusion reaction
           
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SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Nasopharyngitis
  • Arthralgia
  • Headache
  • Nausea
  • Pyrexia
  • Upper respiratory tract infection
  • Fatigue
  • Malignancy
  • Elevated transaminase has been reported
  • No serious infections
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Fatigue
  • Upper respiratory infections
  • Headache
  • Arthralgia
  • Injection-site reaction
  • Elevated liver enzymes reported during induction
           
Edit Content

SIDE EFFECTS

For more detailed information regarding side effects, please refer to the appropriate product monograph.

  • Nasopharyngitis
  • Opportunistic infections
  • Upper respiratory tract infections
  • Herpes zoster
  • CPK elevation
  • Liver enzyme increase
  • Neutropenia
           

IV: intravenous, wk: week, TB: tuberculosis, CHF: congestive heart failure, Anti-TNF: Anti-tumour necrosis factor, HBV: hepatitis B virus, NMSC: non-melanoma skin cancer, CPK: Creatine phosphokinase